Abstract
This descriptive, cross-sectional study was carried out to explore the frequency of contamination with TORCH agents in neonates with congenital malformations in a referral centre in Gorgan city, Islamic Republic of Iran. Blood samples were taken from 64 neonates and their mothers over a 20-month period in 2003-04. Serologic tests showed that 4/64 infants born with congenital malformations (6%) had positive 1 gM antibody titres for Texoplasma gondil (2 cases), rubella virus (1 case) and cytomegalovirus (1 case). 1 gM was positive in 9/63 mothers (14%), also for T. gondil (3 cases), rubella virus (3 cases) and cytomegalovirus (3 cases). No cases of herpes simplex virus type II or Treponema pallidum were found.
MeSH terms
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Adult
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Animals
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Antibodies, Protozoan / blood
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Antibodies, Viral / blood
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Causality
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Congenital Abnormalities / epidemiology
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Congenital Abnormalities / etiology*
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Cross-Sectional Studies
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Cytomegalovirus / immunology
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Cytomegalovirus Infections / blood
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Cytomegalovirus Infections / complications*
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Cytomegalovirus Infections / epidemiology
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Cytomegalovirus Infections / immunology
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Female
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Humans
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Immunoglobulin M / blood
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Infant, Newborn
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Iran / epidemiology
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Male
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Population Surveillance
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Pregnancy
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Pregnancy Complications, Infectious* / blood
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Pregnancy Complications, Infectious* / epidemiology
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Pregnancy Complications, Infectious* / immunology
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Rubella / blood
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Rubella / complications*
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Rubella / epidemiology
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Rubella / immunology
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Rubella virus / immunology
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Toxoplasma / immunology
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Toxoplasmosis, Congenital / blood
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Toxoplasmosis, Congenital / complications*
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Toxoplasmosis, Congenital / epidemiology
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Toxoplasmosis, Congenital / immunology
Substances
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Antibodies, Protozoan
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Antibodies, Viral
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Immunoglobulin M